Assay Detail
Functional
CHEMBL832304
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration against human immunodeficiency virus type 1 in CEM cells
14
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Application of phosphoramidate pronucleotide technology to abacavir leads to a significant enhancement of antiviral potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.20 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL372855 | — | — | 1 | 7.30 |
| CHEMBL193407 | — | — | 1 | 7.30 |
| CHEMBL365518 | — | — | 1 | 7.17 |
| CHEMBL192616 | — | — | 1 | 7.16 |
| CHEMBL363345 | — | — | 1 | 6.16 |
| CHEMBL191973 | — | — | 1 | 5.92 |
| CHEMBL363136 | — | — | 1 | 5.89 |
| CHEMBL364683 | — | — | 1 | 5.85 |
| CHEMBL190873 | — | — | 1 | 5.75 |
| CHEMBL1380 | ABACAVIR | 4.0 | 2 | 5.72 |
| CHEMBL372283 | CARBOVIR | — | 2 | 5.70 |
| CHEMBL366192 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL372855 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL193407 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL365518 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL192616 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL363345 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL191973 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL363136 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL364683 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL190873 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1380 | ABACAVIR | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1380 | ABACAVIR | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL372283 | CARBOVIR | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL372283 | CARBOVIR | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL366192 | — | EC50 | = | 3700.0 | nM | 5.43 |