Assay Detail
Functional
CHEMBL832305
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration against human immunodeficiency virus type 1 in MT-4 cells
16
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Application of phosphoramidate pronucleotide technology to abacavir leads to a significant enhancement of antiviral potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 6.38 | 7.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL363345 | — | — | 4 | 7.81 |
| CHEMBL372855 | — | — | 4 | 7.57 |
| CHEMBL365518 | — | — | 1 | 6.85 |
| CHEMBL193407 | — | — | 1 | 6.70 |
| CHEMBL1380 | ABACAVIR | 4.0 | 2 | 5.67 |
| CHEMBL364683 | — | — | 1 | 5.47 |
| CHEMBL366192 | — | — | 1 | 5.18 |
| CHEMBL191973 | — | — | 1 | 5.18 |
| CHEMBL190873 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL363345 | — | EC50 | = | 15.5 | nM | 7.81 |
| CHEMBL372855 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL372855 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL372855 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL365518 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL363345 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL372855 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL363345 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL193407 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL363345 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1380 | ABACAVIR | EC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL364683 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL1380 | ABACAVIR | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL366192 | — | EC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL191973 | — | EC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL190873 | — | EC50 | = | 7200.0 | nM | 5.14 |