Assay Detail
Functional
CHEMBL832306
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration against human immunodeficiency virus type 1 in PBL cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | PBL |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Application of phosphoramidate pronucleotide technology to abacavir leads to a significant enhancement of antiviral potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.26 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL192616 | — | — | 1 | 8.10 |
| CHEMBL372283 | CARBOVIR | — | 1 | 7.52 |
| CHEMBL1380 | ABACAVIR | 4.0 | 1 | 6.70 |
| CHEMBL363136 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL192616 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL372283 | CARBOVIR | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1380 | ABACAVIR | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL363136 | — | EC50 | = | 200.0 | nM | 6.70 |