Assay Detail
Functional
CHEMBL832308
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Effective concentration against human immunodeficiency virus type 2 in CEM cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 2 |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 2 (CHEMBL380) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 2 |
Publication
Application of phosphoramidate pronucleotide technology to abacavir leads to a significant enhancement of antiviral potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.27 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL372855 | — | — | 1 | 7.30 |
| CHEMBL193407 | — | — | 1 | 7.30 |
| CHEMBL363345 | — | — | 1 | 7.21 |
| CHEMBL365518 | — | — | 1 | 7.19 |
| CHEMBL190873 | — | — | 1 | 5.70 |
| CHEMBL372283 | CARBOVIR | — | 1 | 5.64 |
| CHEMBL1380 | ABACAVIR | 4.0 | 1 | 5.52 |
| CHEMBL364683 | — | — | 1 | 5.35 |
| CHEMBL366192 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL372855 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL193407 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL363345 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL365518 | — | EC50 | = | 64.0 | nM | 7.19 |
| CHEMBL190873 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL372283 | CARBOVIR | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1380 | ABACAVIR | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL364683 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL366192 | — | EC50 | = | 6000.0 | nM | 5.22 |