Assay Detail
Functional
CHEMBL832309
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration against human immunodeficiency virus type 2 in MT-4 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 2 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 2 (CHEMBL380) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 2 |
Publication
Application of phosphoramidate pronucleotide technology to abacavir leads to a significant enhancement of antiviral potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.95 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365518 | — | — | 1 | 6.96 |
| CHEMBL363345 | — | — | 1 | 6.68 |
| CHEMBL372855 | — | — | 1 | 6.58 |
| CHEMBL193407 | — | — | 1 | 6.58 |
| CHEMBL366192 | — | — | 1 | 5.47 |
| CHEMBL191973 | — | — | 1 | 5.47 |
| CHEMBL364683 | — | — | 1 | 5.39 |
| CHEMBL190873 | — | — | 1 | 5.27 |
| CHEMBL1380 | ABACAVIR | 4.0 | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365518 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL363345 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL372855 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL193407 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL366192 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL191973 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL364683 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL190873 | — | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL1380 | ABACAVIR | EC50 | = | 7300.0 | nM | 5.14 |