Assay Detail
Binding
CHEMBL832322
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Inhibitory concentration against isolated rabbit reticulocyte 15-lipoxygenase measured in the presence of linoleic acid
55
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid lipoxygenase ALOX15 (CHEMBL4358) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 55 | 6.88 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL179335 | — | — | 1 | 8.22 |
| CHEMBL426423 | — | — | 1 | 8.10 |
| CHEMBL178139 | — | — | 1 | 8.00 |
| CHEMBL3706765 | — | — | 1 | 8.00 |
| CHEMBL178613 | — | — | 1 | 8.00 |
| CHEMBL362689 | — | — | 1 | 7.96 |
| CHEMBL181226 | — | — | 1 | 7.96 |
| CHEMBL179959 | — | — | 1 | 7.96 |
| CHEMBL180052 | — | — | 1 | 7.92 |
| CHEMBL178920 | — | — | 1 | 7.89 |
| CHEMBL361315 | — | — | 1 | 7.82 |
| CHEMBL368254 | — | — | 1 | 7.60 |
| CHEMBL181220 | — | — | 1 | 7.57 |
| CHEMBL362645 | — | — | 1 | 7.55 |
| CHEMBL178575 | — | — | 1 | 7.52 |
| CHEMBL181409 | — | — | 1 | 7.50 |
| CHEMBL433557 | — | — | 1 | 7.43 |
| CHEMBL180838 | — | — | 1 | 7.38 |
| CHEMBL427319 | — | — | 1 | 7.33 |
| CHEMBL425336 | — | — | 1 | 7.33 |
| CHEMBL360042 | — | — | 1 | 7.21 |
| CHEMBL181837 | — | — | 1 | 7.12 |
| CHEMBL180769 | — | — | 1 | 7.05 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | — | 1 | 6.96 |
| CHEMBL433952 | — | — | 1 | 6.96 |
| CHEMBL181028 | — | — | 1 | 6.96 |
| CHEMBL180256 | — | — | 1 | 6.96 |
| CHEMBL263232 | — | — | 1 | 6.84 |
| CHEMBL369787 | — | — | 1 | 6.63 |
| CHEMBL369336 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL179335 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL426423 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3706765 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL178613 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL178139 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL362689 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL181226 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL179959 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL180052 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL178920 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL361315 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL368254 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL181220 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL362645 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL178575 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL181409 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL433557 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL180838 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL427319 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL425336 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL360042 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL181837 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL180769 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL180256 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL181028 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL433952 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL263232 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL369787 | — | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL369336 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL361639 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL178178 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL425166 | JASPAQUINOL | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL181743 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL425695 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL360987 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL181128 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL181993 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL178495 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL178611 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL180947 | JASPIC ACID | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL180979 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL359834 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL360890 | — | IC50 | = | 3070.0 | nM | 5.51 |
| CHEMBL179844 | — | IC50 | = | 3130.0 | nM | 5.50 |
| CHEMBL433554 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL360222 | — | IC50 | = | 3730.0 | nM | 5.43 |
| CHEMBL180917 | — | IC50 | = | 3810.0 | nM | 5.42 |
| CHEMBL181340 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL426595 | — | IC50 | > | 10000.0 | nM | - |