Assay Detail
Binding
CHEMBL832325
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit binding of [125I]MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanin-concentrating hormone receptor 1 (CHEMBL344) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.62 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL181813 | — | — | 1 | 9.05 |
| CHEMBL362009 | — | — | 1 | 9.00 |
| CHEMBL186548 | — | — | 1 | 8.92 |
| CHEMBL363909 | — | — | 1 | 8.66 |
| CHEMBL362501 | — | — | 1 | 8.57 |
| CHEMBL182261 | — | — | 1 | 8.52 |
| CHEMBL363664 | — | — | 1 | 8.30 |
| CHEMBL184609 | — | — | 1 | 7.69 |
| CHEMBL364983 | — | — | 1 | 7.59 |
| CHEMBL364540 | — | — | 1 | 7.41 |
| CHEMBL185266 | — | — | 1 | 7.39 |
| CHEMBL185558 | — | — | 1 | 7.16 |
| CHEMBL360620 | — | — | 1 | 7.16 |
| CHEMBL364377 | — | — | 1 | 7.05 |
| CHEMBL183468 | — | — | 1 | 7.05 |
| CHEMBL361305 | — | — | 1 | 6.92 |
| CHEMBL184277 | — | — | 1 | 6.83 |
| CHEMBL184482 | — | — | 1 | 6.68 |
| CHEMBL365876 | — | — | 1 | 6.24 |
| CHEMBL184437 | — | — | 1 | 6.14 |
| CHEMBL184692 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL181813 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL362009 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL186548 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL363909 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL362501 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL182261 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL363664 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL184609 | — | IC50 | = | 20.5 | nM | 7.69 |
| CHEMBL364983 | — | IC50 | = | 25.6 | nM | 7.59 |
| CHEMBL364540 | — | IC50 | = | 38.6 | nM | 7.41 |
| CHEMBL185266 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL185558 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL360620 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL364377 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL183468 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL361305 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL184277 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL184482 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL365876 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL184437 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL184692 | — | IC50 | > | 2000.0 | nM | - |