Compound Detail
CHEMBL186548
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Basic Information
| ChEMBL ID | CHEMBL186548 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UHSGLDYWKWJJLG-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
361.5
MW (Da)
4.67
ALogP
4
HBA
1
HBD
51.4
PSA (Ų)
0.72
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Melanin-concentrating hormone receptor 1 CHEMBL344 | IC50 | 8.92 | 8.095 | 1.2 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Melanin-concentrating hormone receptor 1 | IC50 | = | 1.2 | nM | 8.92 | Concentration required to inhibit binding of [125I]MCH radioligand to human Mela... | 15341944 |
| Melanin-concentrating hormone receptor 1 | IC50 | = | 53.3 | nM | 7.27 | Concentration required to inhibit 50% of melanin-concentrating hormone induced [... | 15341944 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15341944 | 10.1016/j.bmcl.2004.07.035 | Melanin-concentrating hormone receptor 1 | 2 |
Data from ChEMBL 36 via Core Engine