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Assay Detail

CHEMBL832364

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Functional
Antiproliferative activity against human cancer SNB-78 cell line
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SNB-78
Confidence 1 — Organism
Curated By Expert

Target

SNB-78 (CHEMBL612543)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents.
Bhat BA, Dhar KL, Puri SC, Saxena AK, Shanmugavel M, Qazi GN.
Bioorg Med Chem Lett (2005) 15 : 3177 -3180
PubMed 15893928 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 4.60 5.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL187822 1 5.00
CHEMBL61998 1 4.86
CHEMBL370537 1 4.85
CHEMBL276600 1 4.78
CHEMBL187875 2 4.68
CHEMBL187451 1 4.66
CHEMBL190381 1 4.65
CHEMBL190474 1 4.64
CHEMBL32353 1 4.64
CHEMBL188132 1 4.59
CHEMBL187437 1 4.54
CHEMBL187681 1 4.48
CHEMBL371800 1 4.27
CHEMBL372678 1 4.13

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL187822 IC50 = 10010.0 nM 5.00
CHEMBL61998 IC50 = 13780.0 nM 4.86
CHEMBL370537 IC50 = 14040.0 nM 4.85
CHEMBL276600 IC50 = 16730.0 nM 4.78
CHEMBL187875 IC50 = 21030.0 nM 4.68
CHEMBL187451 IC50 = 22040.0 nM 4.66
CHEMBL190381 IC50 = 22450.0 nM 4.65
CHEMBL190474 IC50 = 22810.0 nM 4.64
CHEMBL32353 IC50 = 22800.0 nM 4.64
CHEMBL188132 IC50 = 25410.0 nM 4.59
CHEMBL187437 IC50 = 28700.0 nM 4.54
CHEMBL187681 IC50 = 32970.0 nM 4.48
CHEMBL187875 IC50 = 50030.0 nM 4.30
CHEMBL371800 IC50 = 53680.0 nM 4.27
CHEMBL372678 IC50 = 74040.0 nM 4.13