Assay Detail
Binding
CHEMBL832376
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-Ang II from rat liver membrane angiotensin II type 1 (AT1) receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.58 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288174 | — | — | 1 | 8.96 |
| CHEMBL290214 | — | — | 1 | 8.85 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 7.92 |
| CHEMBL157946 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288174 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL290214 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL191 | LOSARTAN | IC50 | = | 12.1 | nM | 7.92 |
| CHEMBL157946 | — | IC50 | > | 10000.0 | nM | - |