Assay Detail
Binding
CHEMBL832395
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Inhibitory activity against Inducible nitric oxide synthase
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.79 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185024 | — | — | 1 | 7.70 |
| CHEMBL363477 | — | — | 1 | 6.80 |
| CHEMBL183012 | — | — | 1 | 6.70 |
| CHEMBL185584 | — | — | 1 | 6.52 |
| CHEMBL360616 | — | — | 1 | 6.30 |
| CHEMBL362148 | — | — | 1 | 6.05 |
| CHEMBL184798 | — | — | 1 | 6.03 |
| CHEMBL185441 | — | — | 1 | 5.92 |
| CHEMBL185161 | — | — | 1 | 5.92 |
| CHEMBL182305 | — | — | 1 | 5.89 |
| CHEMBL359703 | — | — | 1 | 5.82 |
| CHEMBL186142 | — | — | 1 | 5.70 |
| CHEMBL7889 | L-NIL | — | 1 | 5.68 |
| CHEMBL365849 | — | — | 1 | 5.51 |
| CHEMBL365637 | — | — | 1 | 5.46 |
| CHEMBL161318 | — | — | 1 | 5.39 |
| CHEMBL363049 | — | — | 1 | 5.28 |
| CHEMBL360009 | — | — | 1 | 4.99 |
| CHEMBL362366 | — | — | 1 | 4.88 |
| CHEMBL185585 | — | — | 1 | 4.64 |
| CHEMBL361909 | — | — | 1 | 4.41 |
| CHEMBL361419 | — | — | 1 | - |
| CHEMBL185867 | — | — | 1 | - |
| CHEMBL360669 | — | — | 1 | - |
| CHEMBL183268 | — | — | 1 | - |
| CHEMBL185505 | — | — | 1 | - |
| CHEMBL185600 | — | — | 1 | - |
| CHEMBL185535 | — | — | 1 | - |
| CHEMBL364781 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185024 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL363477 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL183012 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL185584 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL360616 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL362148 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL184798 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL185441 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL185161 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL182305 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL359703 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL186142 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL7889 | L-NIL | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL365849 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL365637 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL161318 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL363049 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL360009 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL362366 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL185585 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL361909 | — | IC50 | = | 38700.0 | nM | 4.41 |
| CHEMBL361419 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL185867 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL360669 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL183268 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL185505 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL185600 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL185535 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL364781 | — | IC50 | > | 50000.0 | nM | - |