Assay Detail
Binding
CHEMBL832401
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Inhibitory concentration against Melatonin receptor type 1B
30
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Tetrahydroisoquinoline derivatives as melatonin MT2 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.04 | 8.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL186452 | — | — | 1 | 8.26 |
| CHEMBL187525 | — | — | 1 | 8.01 |
| CHEMBL364816 | — | — | 1 | 8.00 |
| CHEMBL433573 | — | — | 1 | 7.66 |
| CHEMBL365648 | — | — | 1 | 7.62 |
| CHEMBL186941 | — | — | 1 | 7.62 |
| CHEMBL186262 | — | — | 1 | 7.52 |
| CHEMBL187136 | — | — | 1 | 7.35 |
| CHEMBL186590 | — | — | 1 | 7.22 |
| CHEMBL188120 | — | — | 1 | 7.21 |
| CHEMBL187593 | — | — | 1 | 7.12 |
| CHEMBL186451 | — | — | 1 | 7.10 |
| CHEMBL360641 | — | — | 1 | 7.08 |
| CHEMBL366115 | — | — | 1 | 7.00 |
| CHEMBL361458 | — | — | 1 | 6.92 |
| CHEMBL186915 | — | — | 1 | 6.89 |
| CHEMBL186251 | — | — | 1 | 6.85 |
| CHEMBL186866 | — | — | 1 | 6.80 |
| CHEMBL187148 | — | — | 1 | 6.66 |
| CHEMBL365899 | — | — | 2 | 6.62 |
| CHEMBL434916 | — | — | 1 | 6.57 |
| CHEMBL362162 | — | — | 1 | 6.55 |
| CHEMBL185733 | — | — | 1 | 6.43 |
| CHEMBL187592 | — | — | 1 | 6.40 |
| CHEMBL359576 | — | — | 1 | 6.09 |
| CHEMBL186167 | — | — | 1 | 6.00 |
| CHEMBL360213 | — | — | 1 | - |
| CHEMBL187016 | — | — | 1 | - |
| CHEMBL364352 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL186452 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL187525 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL364816 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL433573 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL365648 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL186941 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL186262 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL187136 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL186590 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL188120 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL187593 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL186451 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL360641 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL366115 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL361458 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL186915 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL186251 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL186866 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL187148 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL365899 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL434916 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL362162 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL365899 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL185733 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL187592 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL359576 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL186167 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL187016 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL360213 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL364352 | — | IC50 | > | 1000.0 | nM | - |