Assay Detail
Binding
CHEMBL832425
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Inhibitory concentration against the xeroderma pigmentosum G
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 9.47 | 10.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361962 | — | — | 1 | 10.64 |
| CHEMBL361011 | — | — | 1 | 10.55 |
| CHEMBL183133 | — | — | 1 | 10.21 |
| CHEMBL359533 | — | — | 1 | 10.21 |
| CHEMBL361350 | — | — | 1 | 10.00 |
| CHEMBL182381 | — | — | 1 | 9.89 |
| CHEMBL364591 | — | — | 1 | 9.87 |
| CHEMBL183792 | — | — | 1 | 9.84 |
| CHEMBL183852 | — | — | 1 | 9.80 |
| CHEMBL362842 | — | — | 1 | 9.80 |
| CHEMBL182687 | — | — | 1 | 9.73 |
| CHEMBL183062 | — | — | 1 | 9.70 |
| CHEMBL185325 | — | — | 1 | 9.67 |
| CHEMBL181962 | — | — | 1 | 9.65 |
| CHEMBL359747 | — | — | 1 | 9.64 |
| CHEMBL360615 | — | — | 1 | 9.59 |
| CHEMBL181766 | — | — | 1 | 9.59 |
| CHEMBL183539 | — | — | 1 | 9.56 |
| CHEMBL361546 | — | — | 1 | 9.54 |
| CHEMBL180566 | — | — | 1 | 9.48 |
| CHEMBL185322 | — | — | 1 | 9.26 |
| CHEMBL182077 | — | — | 1 | 9.26 |
| CHEMBL182974 | — | — | 1 | 8.70 |
| CHEMBL182519 | — | — | 1 | 8.52 |
| CHEMBL181709 | — | — | 1 | 8.40 |
| CHEMBL181637 | — | — | 1 | 8.34 |
| CHEMBL362205 | — | — | 1 | 8.07 |
| CHEMBL181907 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361962 | — | IC50 | = | 0.023 | nM | 10.64 |
| CHEMBL361011 | — | IC50 | = | 0.028 | nM | 10.55 |
| CHEMBL183133 | — | IC50 | = | 0.061 | nM | 10.21 |
| CHEMBL359533 | — | IC50 | = | 0.062 | nM | 10.21 |
| CHEMBL361350 | — | IC50 | = | 0.101 | nM | 10.00 |
| CHEMBL182381 | — | IC50 | = | 0.128 | nM | 9.89 |
| CHEMBL364591 | — | IC50 | = | 0.136 | nM | 9.87 |
| CHEMBL183792 | — | IC50 | = | 0.145 | nM | 9.84 |
| CHEMBL183852 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL362842 | — | IC50 | = | 0.157 | nM | 9.80 |
| CHEMBL182687 | — | IC50 | = | 0.185 | nM | 9.73 |
| CHEMBL183062 | — | IC50 | = | 0.202 | nM | 9.70 |
| CHEMBL185325 | — | IC50 | = | 0.215 | nM | 9.67 |
| CHEMBL181962 | — | IC50 | = | 0.226 | nM | 9.65 |
| CHEMBL359747 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL360615 | — | IC50 | = | 0.258 | nM | 9.59 |
| CHEMBL181766 | — | IC50 | = | 0.257 | nM | 9.59 |
| CHEMBL183539 | — | IC50 | = | 0.276 | nM | 9.56 |
| CHEMBL361546 | — | IC50 | = | 0.292 | nM | 9.54 |
| CHEMBL180566 | — | IC50 | = | 0.327 | nM | 9.48 |
| CHEMBL185322 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL182077 | — | IC50 | = | 0.556 | nM | 9.26 |
| CHEMBL182974 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL182519 | — | IC50 | = | 3.04 | nM | 8.52 |
| CHEMBL181709 | — | IC50 | = | 3.99 | nM | 8.40 |
| CHEMBL181637 | — | IC50 | = | 4.62 | nM | 8.34 |
| CHEMBL362205 | — | IC50 | = | 8.45 | nM | 8.07 |
| CHEMBL181907 | — | IC50 | = | 30.2 | nM | 7.52 |