Assay Detail
Binding
CHEMBL832431
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Inhibition of isolated human BuChE
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.29 | 4.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189957 | — | — | 1 | 4.78 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 4.64 |
| CHEMBL364545 | — | — | 1 | 4.40 |
| CHEMBL190060 | — | — | 1 | 4.35 |
| CHEMBL340427 | XANTHOSTIGMINE | — | 1 | 4.32 |
| CHEMBL370961 | — | — | 1 | 4.24 |
| CHEMBL191386 | — | — | 1 | 4.15 |
| CHEMBL365678 | — | — | 1 | 4.13 |
| CHEMBL191461 | — | — | 1 | 4.09 |
| CHEMBL365136 | — | — | 1 | 4.07 |
| CHEMBL372710 | — | — | 1 | 4.02 |
| CHEMBL191416 | — | — | 1 | - |
| CHEMBL190528 | — | — | 1 | - |
| CHEMBL191314 | — | — | 1 | - |
| CHEMBL364678 | — | — | 1 | - |
| CHEMBL363588 | — | — | 1 | - |
| CHEMBL371798 | — | — | 1 | - |
| CHEMBL189797 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189957 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL364545 | — | IC50 | = | 40200.0 | nM | 4.40 |
| CHEMBL190060 | — | IC50 | = | 44300.0 | nM | 4.35 |
| CHEMBL340427 | XANTHOSTIGMINE | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL370961 | — | IC50 | = | 57900.0 | nM | 4.24 |
| CHEMBL191386 | — | IC50 | = | 70300.0 | nM | 4.15 |
| CHEMBL365678 | — | IC50 | = | 74800.0 | nM | 4.13 |
| CHEMBL191461 | — | IC50 | = | 81300.0 | nM | 4.09 |
| CHEMBL365136 | — | IC50 | = | 84400.0 | nM | 4.07 |
| CHEMBL372710 | — | IC50 | = | 94600.0 | nM | 4.02 |
| CHEMBL191416 | — | IC50 | = | 155000.0 | nM | - |
| CHEMBL190528 | — | IC50 | = | 136000.0 | nM | - |
| CHEMBL191314 | — | IC50 | = | 761000.0 | nM | - |
| CHEMBL364678 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL363588 | — | IC50 | = | 153000.0 | nM | - |
| CHEMBL371798 | — | IC50 | = | 4650000.0 | nM | - |
| CHEMBL189797 | — | IC50 | = | 11400000.0 | nM | - |