Assay Detail
Functional
CHEMBL832435
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro agonistic activity against opioid receptor mu of guinea pig ileum
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.14 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL607482 | — | — | 1 | 9.30 |
| CHEMBL607351 | — | — | 1 | 9.05 |
| CHEMBL607407 | — | — | 1 | 9.05 |
| CHEMBL607406 | — | — | 1 | 8.72 |
| CHEMBL607405 | — | — | 1 | 8.70 |
| CHEMBL326684 | — | — | 1 | 8.21 |
| CHEMBL607404 | — | — | 1 | 7.75 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 6.51 |
| CHEMBL607483 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL607482 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL607351 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL607407 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL607406 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL607405 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL326684 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL607404 | — | IC50 | = | 17.6 | nM | 7.75 |
| CHEMBL70 | MORPHINE | IC50 | = | 311.0 | nM | 6.51 |
| CHEMBL607483 | — | IC50 | = | 1000.0 | nM | 6.00 |