Assay Detail
Binding
CHEMBL832458
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Inhibitory activity against Na+/H+ exchanger 1 (NHE-1) expressed in PS120 cells
52
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PS120 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
(5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 52 | 5.80 | 7.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL192227 | — | — | 1 | 7.09 |
| CHEMBL195277 | — | — | 1 | 7.03 |
| CHEMBL192825 | — | — | 1 | 6.92 |
| CHEMBL371801 | — | — | 1 | 6.89 |
| CHEMBL363344 | — | — | 1 | 6.85 |
| CHEMBL193004 | — | — | 1 | 6.85 |
| CHEMBL189789 | — | — | 1 | 6.64 |
| CHEMBL192634 | — | — | 1 | 6.47 |
| CHEMBL189792 | — | — | 1 | 6.32 |
| CHEMBL366228 | — | — | 1 | 6.19 |
| CHEMBL193311 | — | — | 1 | 6.14 |
| CHEMBL192185 | — | — | 1 | 6.12 |
| CHEMBL189970 | — | — | 1 | 5.96 |
| CHEMBL189048 | — | — | 1 | 5.96 |
| CHEMBL436559 | CARIPORIDE | 2.0 | 1 | 5.92 |
| CHEMBL194157 | — | — | 1 | 5.89 |
| CHEMBL366227 | — | — | 1 | 5.89 |
| CHEMBL372051 | — | — | 1 | 5.85 |
| CHEMBL192601 | — | — | 1 | 5.77 |
| CHEMBL192109 | — | — | 1 | 5.77 |
| CHEMBL424813 | — | — | 1 | 5.70 |
| CHEMBL425186 | — | — | 1 | 5.64 |
| CHEMBL370954 | — | — | 1 | 5.64 |
| CHEMBL195160 | — | — | 1 | 5.62 |
| CHEMBL192635 | — | — | 1 | 5.62 |
| CHEMBL373324 | — | — | 1 | 5.58 |
| CHEMBL365153 | — | — | 1 | 5.52 |
| CHEMBL192690 | — | — | 1 | 5.51 |
| CHEMBL364926 | — | — | 1 | 5.46 |
| CHEMBL192664 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL192227 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL195277 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL192825 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL371801 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL363344 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL193004 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL189789 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL192634 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL189792 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL366228 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL193311 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL192185 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL189970 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL189048 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL436559 | CARIPORIDE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL194157 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL366227 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL372051 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL192601 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL192109 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL424813 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL425186 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL370954 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL195160 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL192635 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL373324 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL365153 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL192690 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL364926 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL192664 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL440029 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL190607 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL364735 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL195607 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL364681 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL439854 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL364923 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL192981 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL192250 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL192197 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL436322 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL193121 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL364731 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL195608 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL191456 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL194156 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL192283 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL192284 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL192151 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL191671 | — | IC50 | > | 30000.0 | nM | - |