Assay Detail
Functional
CHEMBL832525
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against HIV-1 double mutants strain 101E and 103N
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
4-benzyl- and 4-benzoyl-3-dimethylaminopyridin-2(1H)-ones, a new family of potent anti-HIV agents: optimization and in vitro evaluation against clinically important HIV mutant strains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.14 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL366692 | — | — | 1 | 8.00 |
| CHEMBL190941 | — | — | 1 | 8.00 |
| CHEMBL188580 | — | — | 1 | 7.70 |
| CHEMBL185715 | — | — | 1 | 7.70 |
| CHEMBL363952 | — | — | 1 | 7.70 |
| CHEMBL188941 | — | — | 1 | 7.40 |
| CHEMBL188223 | — | — | 1 | 7.16 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 6.82 |
| CHEMBL184294 | — | — | 1 | 6.70 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.30 |
| CHEMBL35033 | EMIVIRINE | 2.0 | 1 | 5.10 |
| CHEMBL338047 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL366692 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL190941 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL188580 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL185715 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL363952 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL188941 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL188223 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL184294 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL35033 | EMIVIRINE | IC50 | = | 7940.0 | nM | 5.10 |
| CHEMBL338047 | — | IC50 | - | nM | - |