Assay Detail
Functional
CHEMBL832578
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptor
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RH7777 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.62 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361501 | — | — | 1 | 6.12 |
| CHEMBL188591 | — | — | 1 | 5.66 |
| CHEMBL187633 | PHOSPHORIC ACID MONOTETRADECYL ESTER | — | 1 | 5.64 |
| CHEMBL188859 | — | — | 1 | 5.60 |
| CHEMBL187711 | PHOSPHORIC ACID MONODODECYL ESTER | — | 1 | 5.55 |
| CHEMBL190430 | — | — | 1 | 5.52 |
| CHEMBL191055 | — | — | 1 | 5.26 |
| CHEMBL363776 | — | — | 1 | - |
| CHEMBL188081 | — | — | 1 | - |
| CHEMBL190349 | — | — | 1 | - |
| CHEMBL190999 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361501 | — | IC50 | = | 762.0 | nM | 6.12 |
| CHEMBL188591 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL187633 | PHOSPHORIC ACID MONOTETRADECYL ESTER | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL188859 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL187711 | PHOSPHORIC ACID MONODODECYL ESTER | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL190430 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL191055 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL363776 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL188081 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL190349 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL190999 | — | IC50 | ~ | 10000.0 | nM | - |