Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL832598

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration against human 11-beta-hydroxysteroid dehydrogenase 1
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

11-beta-hydroxysteroid dehydrogenase 1 (CHEMBL4235)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and biological evaluation of sulfonamidooxazoles and beta-keto sulfones: selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.
Xiang J, Ipek M, Suri V, Massefski W, Pan N, Ge Y, Tam M, Xing Y, Tobin JF, Xu X, Tam S.
Bioorg Med Chem Lett (2005) 15 : 2865 -2869
PubMed 15911270 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.02 6.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL383146 1 6.72
CHEMBL341324 1 5.82
CHEMBL197151 1 5.64
CHEMBL383820 1 5.05
CHEMBL371074 1 4.76
CHEMBL425022 1 4.64
CHEMBL196782 1 4.32
CHEMBL196015 1 4.23
CHEMBL372623 1 4.00
CHEMBL194096 1 -
CHEMBL371050 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL383146 IC50 = 190.0 nM 6.72
CHEMBL341324 IC50 = 1500.0 nM 5.82
CHEMBL197151 IC50 = 2300.0 nM 5.64
CHEMBL383820 IC50 = 9000.0 nM 5.05
CHEMBL371074 IC50 = 17300.0 nM 4.76
CHEMBL425022 IC50 = 23000.0 nM 4.64
CHEMBL196782 IC50 = 48000.0 nM 4.32
CHEMBL196015 IC50 = 58700.0 nM 4.23
CHEMBL372623 IC50 = 100000.0 nM 4.00
CHEMBL194096 IC50 > 100000.0 nM -
CHEMBL371050 IC50 > 100000.0 nM -