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Compound Detail

CHEMBL196782

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Cc1c(Cl)cccc1S(=O)(=O)Nc1nc(-c2ccc(C#N)cc2)co1

Basic Information

ChEMBL ID CHEMBL196782
Phase Preclinical
Structure Type MOL
InChI Key RZQWIWDBGOCDMD-UHFFFAOYSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

373.8
MW (Da)
3.98
ALogP
5
HBA
1
HBD
96.0
PSA (Ų)
0.75
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C17H12ClN3O3S
MW 373.82
Aromatic Rings 3
Heavy Atoms 25
NP-Likeness -1.77

Activity Summary

IC50 2 meas. best 4.32

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
11-beta-hydroxysteroid dehydrogenase 1
CHEMBL4235
IC50 4.32 4.32 47863.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
15911270 10.1016/j.bmcl.2005.03.093 11-beta-hydroxysteroid dehydrogenase 1 1
15911270 10.1016/j.bmcl.2005.03.093 11-beta-hydroxysteroid dehydrogenase type 2 1
18314331 10.1016/j.bmcl.2008.02.042 11-beta-hydroxysteroid dehydrogenase 1 1

Data from ChEMBL 36 via Core Engine