Assay Detail
Binding
CHEMBL832600
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Inhibitory concentration against bovine trypsin
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.94 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL176329 | — | — | 1 | 8.24 |
| CHEMBL270437 | — | — | 1 | 7.52 |
| CHEMBL176385 | — | — | 1 | 6.45 |
| CHEMBL366687 | — | — | 1 | 6.27 |
| CHEMBL2096762 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL176329 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL270437 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL176385 | — | IC50 | = | 352.0 | nM | 6.45 |
| CHEMBL366687 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL2096762 | — | IC50 | = | 630.0 | nM | 6.20 |