Assay Detail
Binding
CHEMBL832667
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bindign to recombinant human estrogen receptor alpha
30
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 9.01 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL427324 | — | — | 1 | 9.52 |
| CHEMBL183467 | — | — | 1 | 9.40 |
| CHEMBL361601 | — | — | 1 | 9.40 |
| CHEMBL182794 | — | — | 1 | 9.30 |
| CHEMBL367350 | — | — | 1 | 9.30 |
| CHEMBL182980 | — | — | 1 | 9.30 |
| CHEMBL184202 | — | — | 1 | 9.15 |
| CHEMBL179852 | — | — | 1 | 9.15 |
| CHEMBL183489 | — | — | 1 | 9.15 |
| CHEMBL183263 | — | — | 1 | 9.15 |
| CHEMBL369545 | — | — | 1 | 9.15 |
| CHEMBL367574 | — | — | 1 | 9.15 |
| CHEMBL183344 | — | — | 1 | 9.10 |
| CHEMBL183092 | — | — | 1 | 9.10 |
| CHEMBL304552 | — | — | 1 | 9.10 |
| CHEMBL183371 | — | — | 1 | 9.05 |
| CHEMBL183388 | — | — | 1 | 9.05 |
| CHEMBL182887 | — | — | 1 | 9.00 |
| CHEMBL183049 | — | — | 1 | 9.00 |
| CHEMBL2113027 | — | — | 1 | 8.96 |
| CHEMBL183086 | — | — | 1 | 8.92 |
| CHEMBL180792 | — | — | 2 | 8.89 |
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 8.89 |
| CHEMBL361751 | — | — | 1 | 8.77 |
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 8.74 |
| CHEMBL181944 | — | — | 1 | 8.60 |
| CHEMBL362623 | — | — | 1 | 8.59 |
| CHEMBL183584 | — | — | 1 | 8.52 |
| CHEMBL183044 | — | — | 1 | 8.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL427324 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL183467 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL361601 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL182794 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL367350 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL182980 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL184202 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL183263 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL183489 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL369545 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL179852 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL367574 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL183092 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL183344 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL304552 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL183388 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL183371 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL183049 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL182887 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2113027 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL183086 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL135 | ESTRADIOL | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL180792 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL361751 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL180792 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL81 | RALOXIFENE | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL181944 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL362623 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL183584 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL183044 | — | IC50 | = | 6.3 | nM | 8.20 |