Assay Detail
Binding
CHEMBL832673
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Inhibitory concentration against Epidermal growth factor receptor tyrosine kinase activity
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel, potent and selective anilinoquinazoline and anilinopyrimidine inhibitors of p38 MAP kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.79 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7917 | TYRPHOSTIN AG-1478 | — | 1 | 8.30 |
| CHEMBL186580 | — | — | 1 | 6.31 |
| CHEMBL184682 | — | — | 1 | 6.00 |
| CHEMBL360209 | — | — | 1 | 5.66 |
| CHEMBL182397 | — | — | 1 | 5.55 |
| CHEMBL186747 | — | — | 1 | 5.50 |
| CHEMBL186802 | — | — | 1 | 5.25 |
| CHEMBL185327 | — | — | 1 | 4.96 |
| CHEMBL187007 | — | — | 1 | 4.54 |
| CHEMBL184555 | — | — | 1 | - |
| CHEMBL365830 | — | — | 1 | - |
| CHEMBL364576 | — | — | 1 | - |
| CHEMBL184052 | — | — | 1 | - |
| CHEMBL10 | SB-203580 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7917 | TYRPHOSTIN AG-1478 | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL186580 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL184682 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL360209 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL182397 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL186747 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL186802 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL185327 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL187007 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL184555 | — | IC50 | > | 33000.0 | nM | - |
| CHEMBL365830 | — | IC50 | > | 33000.0 | nM | - |
| CHEMBL364576 | — | IC50 | > | 33000.0 | nM | - |
| CHEMBL184052 | — | IC50 | > | 33000.0 | nM | - |
| CHEMBL10 | SB-203580 | IC50 | > | 33000.0 | nM | - |