Assay Detail
Binding
CHEMBL832699
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Inhibitory concentration against rat dipeptidylpeptidase IV
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
1-((S)-gamma-substituted prolyl)-(S)-2-cyanopyrrolidine as a novel series of highly potent DPP-IV inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 9.00 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL194717 | — | — | 1 | 9.82 |
| CHEMBL370540 | — | — | 1 | 9.77 |
| CHEMBL370046 | — | — | 1 | 9.77 |
| CHEMBL433811 | — | — | 1 | 9.62 |
| CHEMBL371143 | — | — | 1 | 9.59 |
| CHEMBL195420 | — | — | 1 | 9.57 |
| CHEMBL195063 | — | — | 1 | 9.55 |
| CHEMBL195335 | — | — | 1 | 9.28 |
| CHEMBL371585 | — | — | 1 | 8.96 |
| CHEMBL194993 | — | — | 1 | 8.82 |
| CHEMBL77538 | — | — | 1 | 8.64 |
| CHEMBL381626 | — | — | 1 | 8.54 |
| CHEMBL195804 | — | — | 1 | 8.52 |
| CHEMBL192882 | — | — | 1 | 8.44 |
| CHEMBL539939 | — | — | 1 | 8.42 |
| CHEMBL193168 | — | — | 1 | 8.41 |
| CHEMBL192165 | — | — | 1 | 8.17 |
| CHEMBL191699 | — | — | 1 | 8.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL194717 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL370540 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL370046 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL433811 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL371143 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL195420 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL195063 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL195335 | — | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL371585 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL194993 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL77538 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL381626 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL195804 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL192882 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL539939 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL193168 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL192165 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL191699 | — | IC50 | = | 9.1 | nM | 8.04 |