Assay Detail
Binding
CHEMBL832704
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Inhibition of bovine farnesyltransferase
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and activity of achiral analogs of 2-quinolones and indoles as non-thiol farnesyltransferase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 8.15 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL440564 | — | — | 1 | 9.82 |
| CHEMBL380554 | — | — | 1 | 9.24 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 9.19 |
| CHEMBL194073 | — | — | 1 | 9.03 |
| CHEMBL365362 | — | — | 1 | 8.68 |
| CHEMBL194041 | — | — | 1 | 8.42 |
| CHEMBL371818 | — | — | 1 | 8.33 |
| CHEMBL193340 | — | — | 1 | 8.21 |
| CHEMBL194143 | — | — | 1 | 8.14 |
| CHEMBL298734 | LONAFARNIB | 4.0 | 1 | 8.08 |
| CHEMBL194072 | — | — | 1 | 8.00 |
| CHEMBL194172 | — | — | 1 | 7.54 |
| CHEMBL373267 | — | — | 1 | 7.36 |
| CHEMBL364067 | — | — | 1 | 7.10 |
| CHEMBL195553 | — | — | 1 | 7.05 |
| CHEMBL370049 | — | — | 1 | 6.25 |
| CHEMBL194382 | — | — | 1 | - |
| CHEMBL193881 | — | — | 1 | - |
| CHEMBL195730 | — | — | 1 | - |
| CHEMBL195843 | — | — | 1 | - |
| CHEMBL425561 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL440564 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL380554 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL194073 | — | IC50 | = | 0.93 | nM | 9.03 |
| CHEMBL365362 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL194041 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL371818 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL193340 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL194143 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL298734 | LONAFARNIB | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL194072 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL194172 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL373267 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL364067 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL195553 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL370049 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL194382 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL193881 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL195730 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL195843 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL425561 | — | IC50 | > | 1000.0 | nM | - |