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Assay Detail

CHEMBL832708

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration against hepatitis C virus helicase
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Hepacivirus hominis
Confidence 9 — Direct single protein target
Curated By Expert

Target

NS3 (CHEMBL1293269)
Type SINGLE PROTEIN
Organism Hepatitis C virus

Publication

Control of hepatitis C: a medicinal chemistry perspective.
Gordon CP, Keller PA.
J Med Chem (2005) 48 : 1 -20
PubMed 15633995 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.72 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL504459 NOGALAMYCIN 2.0 1 7.00
CHEMBL2368688 1 6.26
CHEMBL298210 1 6.16
CHEMBL417 EPIRUBICIN 4.0 1 6.12
CHEMBL607669 1 5.82
CHEMBL2368690 1 5.82
CHEMBL175888 1 5.26
CHEMBL366398 1 5.16
CHEMBL607670 1 4.92
CHEMBL177820 TETRABROMOBENZOTRIAZOLE 1 4.70
CHEMBL398463 RTP -1.0 1 -
CHEMBL3306225 1 -
CHEMBL428647 PACLITAXEL 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL504459 NOGALAMYCIN IC50 = 100.0 nM 7.00
CHEMBL2368688 IC50 = 550.0 nM 6.26
CHEMBL298210 IC50 = 700.0 nM 6.16
CHEMBL417 EPIRUBICIN IC50 = 750.0 nM 6.12
CHEMBL607669 IC50 = 1500.0 nM 5.82
CHEMBL2368690 IC50 = 1500.0 nM 5.82
CHEMBL175888 IC50 = 5500.0 nM 5.26
CHEMBL366398 IC50 = 7000.0 nM 5.16
CHEMBL607670 IC50 = 12000.0 nM 4.92
CHEMBL177820 TETRABROMOBENZOTRIAZOLE IC50 = 20000.0 nM 4.70
CHEMBL398463 RTP IC50 = 180000.0 nM -
CHEMBL3306225 IC50 = 250000.0 nM -
CHEMBL428647 PACLITAXEL IC50 > 1000.0 nM -