Assay Detail
Binding
CHEMBL832716
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Inhibitory concentration against butyrylcholinesterase of rat serum
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Bis-huperzine B: highly potent and selective acetylcholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.18 | 4.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL176132 | BIS(18)-HUPERZINE B | — | 1 | 4.26 |
| CHEMBL367977 | BIS(9)-HUPERZINE B | — | 1 | 4.22 |
| CHEMBL434898 | BIS(16)-HUPERZINE B | — | 1 | 4.20 |
| CHEMBL175975 | BIS(12)-HUPERZINE B | — | 1 | 4.19 |
| CHEMBL435673 | — | — | 1 | 4.18 |
| CHEMBL368899 | — | — | 1 | 4.17 |
| CHEMBL368897 | BIS(20)-HUPERZINE B | — | 1 | 4.05 |
| CHEMBL245079 | HUPERZINE B | — | 1 | - |
| CHEMBL395280 | HUPERZINE A | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL176132 | BIS(18)-HUPERZINE B | IC50 | = | 54300.0 | nM | 4.26 |
| CHEMBL367977 | BIS(9)-HUPERZINE B | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL434898 | BIS(16)-HUPERZINE B | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL175975 | BIS(12)-HUPERZINE B | IC50 | = | 64500.0 | nM | 4.19 |
| CHEMBL435673 | — | IC50 | = | 65400.0 | nM | 4.18 |
| CHEMBL368899 | — | IC50 | = | 67900.0 | nM | 4.17 |
| CHEMBL368897 | BIS(20)-HUPERZINE B | IC50 | = | 88400.0 | nM | 4.05 |
| CHEMBL245079 | HUPERZINE B | IC50 | = | 227000.0 | nM | - |
| CHEMBL395280 | HUPERZINE A | IC50 | = | 702000.0 | nM | - |