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Assay Detail

CHEMBL832725

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Binding
Inhibitory concentration against quiescent cell proline dipeptidase
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Dipeptidyl peptidase 2 (CHEMBL3976)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of potent and selective beta-homophenylalanine based dipeptidyl peptidase IV inhibitors.
Xu J, Ok HO, Gonzalez EJ, Colwell LF, Habulihaz B, He H, Leiting B, Lyons KA, Marsilio F, Patel RA, Wu JK, Thornberry NA, Weber AE, Parmee ER.
Bioorg Med Chem Lett (2004) 14 : 4759 -4762
PubMed 15324903 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 4.41 5.24

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL366278 1 5.24
CHEMBL184937 1 4.61
CHEMBL185538 1 4.61
CHEMBL363319 1 4.60
CHEMBL405786 1 4.53
CHEMBL184986 1 4.47
CHEMBL184442 1 4.44
CHEMBL182544 1 4.31
CHEMBL184928 1 4.31
CHEMBL187118 1 4.30
CHEMBL184912 1 4.25
CHEMBL363879 1 4.17
CHEMBL433572 1 4.11
CHEMBL185601 1 4.09
CHEMBL185351 1 4.04
CHEMBL185121 1 -
CHEMBL184262 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL366278 IC50 = 5775.0 nM 5.24
CHEMBL184937 IC50 = 24330.0 nM 4.61
CHEMBL185538 IC50 = 24570.0 nM 4.61
CHEMBL363319 IC50 = 25380.0 nM 4.60
CHEMBL405786 IC50 = 29750.0 nM 4.53
CHEMBL184986 IC50 = 33890.0 nM 4.47
CHEMBL184442 IC50 = 36190.0 nM 4.44
CHEMBL182544 IC50 = 48510.0 nM 4.31
CHEMBL184928 IC50 = 48510.0 nM 4.31
CHEMBL187118 IC50 = 49700.0 nM 4.30
CHEMBL184912 IC50 = 56050.0 nM 4.25
CHEMBL363879 IC50 = 67630.0 nM 4.17
CHEMBL433572 IC50 = 77560.0 nM 4.11
CHEMBL185601 IC50 = 82120.0 nM 4.09
CHEMBL185351 IC50 = 92060.0 nM 4.04
CHEMBL185121 IC50 > 100000.0 nM -
CHEMBL184262 IC50 > 100000.0 nM -