Assay Detail
Binding
CHEMBL832744
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against Saccharomyces cerevisiae methionine aminopeptidase 1
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Saccharomyces cerevisiae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Methionine aminopeptidase 1 (CHEMBL2526) ↗| Type | SINGLE PROTEIN |
| Organism | Saccharomyces cerevisiae S288c |
Publication
Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 1: SAR studies on the determination of the key scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.56 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92374 | — | — | 1 | 6.46 |
| CHEMBL313650 | — | — | 1 | 6.21 |
| CHEMBL360513 | — | — | 1 | 6.11 |
| CHEMBL315270 | — | — | 1 | 5.99 |
| CHEMBL359541 | — | — | 1 | 5.61 |
| CHEMBL89671 | — | — | 1 | 5.16 |
| CHEMBL183436 | — | — | 1 | 4.77 |
| CHEMBL179906 | — | — | 1 | 4.20 |
| CHEMBL361359 | — | — | 1 | - |
| CHEMBL359929 | — | — | 1 | - |
| CHEMBL361849 | — | — | 1 | - |
| CHEMBL182901 | — | — | 1 | - |
| CHEMBL182954 | — | — | 1 | - |
| CHEMBL183346 | — | — | 1 | - |
| CHEMBL183861 | — | — | 1 | - |
| CHEMBL183652 | — | — | 1 | - |
| CHEMBL183821 | — | — | 1 | - |
| CHEMBL181349 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92374 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL313650 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL360513 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL315270 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL359541 | — | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL89671 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL183436 | — | IC50 | = | 17040.0 | nM | 4.77 |
| CHEMBL179906 | — | IC50 | = | 62860.0 | nM | 4.20 |
| CHEMBL361359 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL359929 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL361849 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL182901 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL182954 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL183346 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL183861 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL183652 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL183821 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL181349 | — | IC50 | > | 100000.0 | nM | - |