Compound Detail
CHEMBL183436
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL183436 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VQIGUODXCODGBE-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
278.3
MW (Da)
1.22
ALogP
6
HBA
2
HBD
93.2
PSA (Ų)
0.82
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Methionine aminopeptidase CHEMBL3423 | IC50 | 5.7 | 5.7 | 1980.0 | 1 |
| Methionine aminopeptidase 1 CHEMBL2526 | IC50 | 4.77 | 4.77 | 17040.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Methionine aminopeptidase | IC50 | = | 1980.0 | nM | 5.7 | Inhibitory concentration against Escherichia coli methionine aminopeptidase 1 | 15664828 |
| Methionine aminopeptidase 1 | IC50 | = | 17040.0 | nM | 4.77 | Inhibitory concentration against Saccharomyces cerevisiae methionine aminopeptid... | 15664828 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15664828 | 10.1016/j.bmcl.2004.11.034 | Methionine aminopeptidase | 1 |
| 15664828 | 10.1016/j.bmcl.2004.11.034 | Methionine aminopeptidase 1 | 1 |
Data from ChEMBL 36 via Core Engine