Assay Detail
Binding
CHEMBL828659
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Inhibitory concentration against Escherichia coli methionine aminopeptidase 1
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 1: SAR studies on the determination of the key scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.58 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92374 | — | — | 1 | 6.58 |
| CHEMBL313650 | — | — | 1 | 6.42 |
| CHEMBL359929 | — | — | 1 | 6.00 |
| CHEMBL315270 | — | — | 1 | 5.91 |
| CHEMBL360513 | — | — | 1 | 5.85 |
| CHEMBL183436 | — | — | 1 | 5.70 |
| CHEMBL359541 | — | — | 1 | 5.68 |
| CHEMBL183652 | — | — | 1 | 5.63 |
| CHEMBL181349 | — | — | 1 | 5.35 |
| CHEMBL183136 | — | — | 1 | 5.35 |
| CHEMBL89671 | — | — | 1 | 5.30 |
| CHEMBL360927 | — | — | 1 | 5.24 |
| CHEMBL362218 | — | — | 1 | 5.24 |
| CHEMBL183861 | — | — | 1 | 5.17 |
| CHEMBL182901 | — | — | 1 | 5.04 |
| CHEMBL179906 | — | — | 1 | 4.89 |
| CHEMBL182954 | — | — | 1 | - |
| CHEMBL183821 | — | — | 1 | - |
| CHEMBL361849 | — | — | 1 | - |
| CHEMBL361359 | — | — | 1 | - |
| CHEMBL181520 | — | — | 1 | - |
| CHEMBL183346 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92374 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL313650 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL359929 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL315270 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL360513 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL183436 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL359541 | — | IC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL183652 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL181349 | — | IC50 | = | 4510.0 | nM | 5.35 |
| CHEMBL183136 | — | IC50 | = | 4490.0 | nM | 5.35 |
| CHEMBL89671 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL360927 | — | IC50 | = | 5820.0 | nM | 5.24 |
| CHEMBL362218 | — | IC50 | = | 5820.0 | nM | 5.24 |
| CHEMBL183861 | — | IC50 | = | 6710.0 | nM | 5.17 |
| CHEMBL182901 | — | IC50 | = | 9220.0 | nM | 5.04 |
| CHEMBL179906 | — | IC50 | = | 12780.0 | nM | 4.89 |
| CHEMBL182954 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL183821 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL361849 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL361359 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL181520 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL183346 | — | IC50 | > | 100000.0 | nM | - |