Assay Detail
Binding
CHEMBL832762
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tubulin polymerization upon incubation for 20 min at 30 degree C
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.19 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL192860 | — | — | 1 | 5.96 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.92 |
| CHEMBL192224 | — | — | 1 | 5.58 |
| CHEMBL371487 | — | — | 1 | 5.55 |
| CHEMBL192841 | — | — | 1 | 5.19 |
| CHEMBL540358 | — | — | 1 | 5.12 |
| CHEMBL195287 | — | — | 1 | 4.85 |
| CHEMBL536726 | — | — | 1 | 4.70 |
| CHEMBL191624 | — | — | 1 | 4.51 |
| CHEMBL36455 | E-COMBRETASTATIN A-4 | — | 1 | 4.48 |
| CHEMBL535375 | — | — | 1 | - |
| CHEMBL541122 | — | — | 1 | - |
| CHEMBL537854 | — | — | 1 | - |
| CHEMBL537189 | — | — | 1 | - |
| CHEMBL536497 | — | — | 1 | - |
| CHEMBL535601 | — | — | 1 | - |
| CHEMBL195691 | — | — | 1 | - |
| CHEMBL195219 | — | — | 1 | - |
| CHEMBL192166 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL192860 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL192224 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL371487 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL192841 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL540358 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL195287 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL536726 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL191624 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL36455 | E-COMBRETASTATIN A-4 | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL535375 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL541122 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL537854 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL537189 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL536497 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL535601 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL195691 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL195219 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL192166 | — | IC50 | > | 40000.0 | nM | - |