Assay Detail
Binding
CHEMBL832763
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Inhibitory activity against Acetylcholinesterase enzyme using human AChE assay
69
Total Activities
68
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A docking score function for estimating ligand-protein interactions: application to acetylcholinesterase inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 69 | 7.29 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL359570 | ICOPEZIL | 2.0 | 1 | 9.48 |
| CHEMBL426441 | — | — | 1 | 9.32 |
| CHEMBL329231 | — | — | 1 | 9.24 |
| CHEMBL93936 | — | — | 1 | 9.10 |
| CHEMBL328468 | — | — | 1 | 9.02 |
| CHEMBL187818 | — | — | 1 | 8.59 |
| CHEMBL92736 | — | — | 1 | 8.55 |
| CHEMBL95020 | — | — | 1 | 8.44 |
| CHEMBL610242 | — | — | 1 | 8.35 |
| CHEMBL186042 | — | — | 1 | 8.34 |
| CHEMBL188823 | — | — | 1 | 8.24 |
| CHEMBL362752 | — | — | 1 | 8.22 |
| CHEMBL189122 | — | — | 1 | 8.20 |
| CHEMBL186264 | — | — | 1 | 8.15 |
| CHEMBL93619 | — | — | 1 | 8.15 |
| CHEMBL94186 | — | — | 1 | 8.14 |
| CHEMBL433379 | — | — | 1 | 8.11 |
| CHEMBL186144 | — | — | 1 | 8.10 |
| CHEMBL418955 | — | — | 1 | 8.08 |
| CHEMBL92663 | — | — | 1 | 8.06 |
| CHEMBL93241 | — | — | 1 | 8.05 |
| CHEMBL93123 | — | — | 1 | 8.03 |
| CHEMBL92955 | — | — | 1 | 7.85 |
| CHEMBL420625 | — | — | 1 | 7.70 |
| CHEMBL87014 | — | — | 1 | 7.66 |
| CHEMBL92463 | — | — | 1 | 7.58 |
| CHEMBL372491 | — | — | 1 | 7.55 |
| CHEMBL189774 | — | — | 1 | 7.52 |
| CHEMBL610243 | — | — | 1 | 7.50 |
| CHEMBL365904 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL359570 | ICOPEZIL | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL426441 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL329231 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL93936 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL328468 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL187818 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL92736 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL95020 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL610242 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL186042 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL188823 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL362752 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL189122 | — | IC50 | = | 6.27 | nM | 8.20 |
| CHEMBL93619 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL186264 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL94186 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL433379 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL186144 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL418955 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL92663 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL93241 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL93123 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL92955 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL420625 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL87014 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL92463 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL372491 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL189774 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL610243 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL365904 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL313231 | — | IC50 | = | 41.5 | nM | 7.38 |
| CHEMBL361869 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL87823 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL330004 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL364125 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL188714 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL92460 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL364585 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL360832 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL92775 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL328102 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL86031 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL189517 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL362711 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL185976 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL432376 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL92958 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL313582 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL187603 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL92460 | — | IC50 | = | 210.0 | nM | 6.68 |