Assay Detail
Binding
CHEMBL832790
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists: effects of fused heterocycles on antiviral activity and pharmacokinetic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 8.43 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20896 | — | — | 1 | 10.00 |
| CHEMBL194497 | — | — | 1 | 9.52 |
| CHEMBL193984 | — | — | 1 | 9.46 |
| CHEMBL2113086 | — | — | 1 | 9.38 |
| CHEMBL371177 | — | — | 1 | 9.30 |
| CHEMBL195753 | — | — | 1 | 9.22 |
| CHEMBL193822 | — | — | 1 | 9.10 |
| CHEMBL435886 | — | — | 1 | 9.09 |
| CHEMBL193440 | — | — | 1 | 9.08 |
| CHEMBL193988 | — | — | 1 | 9.05 |
| CHEMBL2113088 | — | — | 1 | 9.00 |
| CHEMBL364070 | — | — | 1 | 8.60 |
| CHEMBL193972 | — | — | 1 | 8.59 |
| CHEMBL436290 | — | — | 1 | 8.55 |
| CHEMBL475606 | — | — | 1 | 8.52 |
| CHEMBL472798 | — | — | 1 | 8.46 |
| CHEMBL191139 | — | — | 1 | 8.20 |
| CHEMBL2113084 | — | — | 1 | 8.15 |
| CHEMBL196087 | — | — | 1 | 8.09 |
| CHEMBL445925 | — | — | 1 | 8.00 |
| CHEMBL191803 | — | — | 1 | 7.92 |
| CHEMBL194078 | — | — | 1 | 7.92 |
| CHEMBL470512 | — | — | 1 | 7.89 |
| CHEMBL195930 | — | — | 1 | 7.64 |
| CHEMBL472799 | — | — | 1 | 7.54 |
| CHEMBL195199 | — | — | 1 | 7.20 |
| CHEMBL475777 | — | — | 1 | 7.19 |
| CHEMBL192456 | — | — | 1 | 7.00 |
| CHEMBL363564 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20896 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL194497 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL193984 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL2113086 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL371177 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL195753 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL193822 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL435886 | — | IC50 | = | 0.82 | nM | 9.09 |
| CHEMBL193440 | — | IC50 | = | 0.84 | nM | 9.08 |
| CHEMBL193988 | — | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL2113088 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL364070 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL193972 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL436290 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL475606 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL472798 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL191139 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL2113084 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL196087 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL445925 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL191803 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL194078 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL470512 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL195930 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL472799 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL195199 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL475777 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL192456 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL363564 | — | IC50 | = | 200.0 | nM | 6.70 |