Assay Detail
Binding
CHEMBL832846
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Inhibition of bovine geranylgeranyl transferase
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and activity of achiral analogs of 2-quinolones and indoles as non-thiol farnesyltransferase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.93 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL440564 | — | — | 1 | 6.96 |
| CHEMBL380554 | — | — | 1 | 6.85 |
| CHEMBL194073 | — | — | 1 | 6.57 |
| CHEMBL193340 | — | — | 1 | 6.28 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 5.96 |
| CHEMBL194072 | — | — | 1 | 5.40 |
| CHEMBL371818 | — | — | 1 | 4.77 |
| CHEMBL194041 | — | — | 1 | 4.66 |
| CHEMBL194172 | — | — | 1 | - |
| CHEMBL365362 | — | — | 1 | - |
| CHEMBL194143 | — | — | 1 | - |
| CHEMBL195553 | — | — | 1 | - |
| CHEMBL364067 | — | — | 1 | - |
| CHEMBL298734 | LONAFARNIB | 4.0 | 1 | - |
| CHEMBL373267 | — | — | 1 | - |
| CHEMBL194382 | — | — | 1 | - |
| CHEMBL193881 | — | — | 1 | - |
| CHEMBL195730 | — | — | 1 | - |
| CHEMBL370049 | — | — | 1 | - |
| CHEMBL195843 | — | — | 1 | - |
| CHEMBL425561 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL440564 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL380554 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL194073 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL193340 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL194072 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL371818 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL194041 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL194172 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL365362 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL194143 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL195553 | — | IC50 | - | nM | - | |
| CHEMBL364067 | — | IC50 | - | nM | - | |
| CHEMBL298734 | LONAFARNIB | IC50 | > | 10000.0 | nM | - |
| CHEMBL373267 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL194382 | — | IC50 | - | nM | - | |
| CHEMBL193881 | — | IC50 | - | nM | - | |
| CHEMBL195730 | — | IC50 | - | nM | - | |
| CHEMBL370049 | — | IC50 | - | nM | - | |
| CHEMBL195843 | — | IC50 | - | nM | - | |
| CHEMBL425561 | — | IC50 | > | 1000.0 | nM | - |