Assay Detail
Binding
CHEMBL832849
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Inhibitory concentration against matrix metalloprotease-1 at 1 uM
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and SAR of diazepine and thiazepine TACE and MMP inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.43 | 7.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL359502 | — | — | 1 | 7.04 |
| CHEMBL369302 | — | — | 1 | 6.95 |
| CHEMBL181328 | — | — | 1 | 6.94 |
| CHEMBL361959 | — | — | 1 | 6.85 |
| CHEMBL180181 | — | — | 1 | 6.77 |
| CHEMBL178732 | — | — | 1 | 6.68 |
| CHEMBL180333 | — | — | 1 | 6.67 |
| CHEMBL180130 | — | — | 1 | 6.62 |
| CHEMBL360257 | — | — | 1 | 6.56 |
| CHEMBL178929 | — | — | 1 | 6.56 |
| CHEMBL181208 | — | — | 1 | 6.54 |
| CHEMBL183132 | — | — | 1 | 6.54 |
| CHEMBL180047 | — | — | 1 | 6.48 |
| CHEMBL180484 | — | — | 1 | 6.44 |
| CHEMBL362797 | — | — | 1 | 6.39 |
| CHEMBL359920 | — | — | 1 | 6.24 |
| CHEMBL361809 | — | — | 1 | 6.19 |
| CHEMBL181365 | — | — | 1 | 5.95 |
| CHEMBL180891 | — | — | 1 | 5.67 |
| CHEMBL180410 | — | — | 1 | 5.52 |
| CHEMBL369574 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL359502 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL369302 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL181328 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL361959 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL180181 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL178732 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL180333 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL180130 | — | IC50 | = | 238.0 | nM | 6.62 |
| CHEMBL360257 | — | IC50 | = | 274.0 | nM | 6.56 |
| CHEMBL178929 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL181208 | — | IC50 | = | 285.0 | nM | 6.54 |
| CHEMBL183132 | — | IC50 | = | 287.0 | nM | 6.54 |
| CHEMBL180047 | — | IC50 | = | 334.0 | nM | 6.48 |
| CHEMBL180484 | — | IC50 | = | 362.0 | nM | 6.44 |
| CHEMBL362797 | — | IC50 | = | 408.0 | nM | 6.39 |
| CHEMBL359920 | — | IC50 | = | 576.0 | nM | 6.24 |
| CHEMBL361809 | — | IC50 | = | 645.0 | nM | 6.19 |
| CHEMBL181365 | — | IC50 | = | 1136.0 | nM | 5.95 |
| CHEMBL180891 | — | IC50 | = | 2117.0 | nM | 5.67 |
| CHEMBL180410 | — | IC50 | = | 3031.0 | nM | 5.52 |
| CHEMBL369574 | — | IC50 | = | 4584.0 | nM | 5.34 |