Assay Detail
Binding
CHEMBL832851
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Potency towards cytochrome P 450 26 enzyme activity
31
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potent and selective [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines as retinoic acid metabolic blocking agents (RAMBAs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.47 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL368448 | — | — | 2 | 8.48 |
| CHEMBL426789 | — | — | 2 | 8.46 |
| CHEMBL359627 | — | — | 2 | 8.22 |
| CHEMBL181309 | — | — | 2 | 8.15 |
| CHEMBL179550 | — | — | 1 | 8.10 |
| CHEMBL360072 | — | — | 1 | 7.84 |
| CHEMBL178474 | — | — | 2 | 7.80 |
| CHEMBL362412 | — | — | 2 | 7.72 |
| CHEMBL360771 | — | — | 2 | 7.70 |
| CHEMBL180805 | — | — | 2 | 7.67 |
| CHEMBL180348 | — | — | 1 | 7.60 |
| CHEMBL181385 | — | — | 2 | 7.47 |
| CHEMBL367357 | — | — | 1 | 7.46 |
| CHEMBL182438 | — | — | 1 | 7.43 |
| CHEMBL362489 | — | — | 1 | 7.33 |
| CHEMBL360148 | — | — | 1 | 7.32 |
| CHEMBL180856 | — | — | 1 | 7.30 |
| CHEMBL180829 | — | — | 1 | 7.27 |
| CHEMBL180592 | — | — | 1 | 7.11 |
| CHEMBL179825 | — | — | 1 | 7.00 |
| CHEMBL178873 | — | — | 1 | 6.47 |
| CHEMBL389433 | LIAROZOLE | 2.0 | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL368448 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL426789 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL359627 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL426789 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL181309 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL179550 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL368448 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL360072 | — | IC50 | = | 14.4 | nM | 7.84 |
| CHEMBL178474 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL181309 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL362412 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL360771 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL180805 | — | IC50 | = | 21.4 | nM | 7.67 |
| CHEMBL180348 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL181385 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL367357 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL182438 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL360771 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL362489 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL360148 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL180856 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL180829 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL359627 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL180805 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL180592 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL178474 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL181385 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL179825 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL362412 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL178873 | — | IC50 | = | 335.0 | nM | 6.47 |
| CHEMBL389433 | LIAROZOLE | IC50 | = | 6000.0 | nM | 5.22 |