Assay Detail
Binding
CHEMBL832875
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against serotonin 5-hydroxytryptamine 1A receptor using radioligand [3H]8-OH-DPAT binding assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as potential antipsychotic agents: synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.46 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109101 | — | — | 1 | 7.16 |
| CHEMBL108463 | — | — | 1 | 6.26 |
| CHEMBL110489 | — | — | 1 | 6.23 |
| CHEMBL109063 | — | — | 1 | 6.20 |
| CHEMBL108531 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109101 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL108463 | — | Ki | = | 555.0 | nM | 6.26 |
| CHEMBL110489 | — | Ki | = | 593.0 | nM | 6.23 |
| CHEMBL109063 | — | Ki | = | 632.0 | nM | 6.20 |
| CHEMBL108531 | — | Ki | > | 10000.0 | nM | - |