Assay Detail
Binding
CHEMBL832888
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Inhibition of Acetylcholinesterase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.49 | 8.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL179455 | — | — | 1 | 8.81 |
| CHEMBL11805 | CAPROCTAMINE | — | 1 | 6.77 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.37 |
| CHEMBL361165 | — | — | 1 | 6.02 |
| CHEMBL345124 | PROPIDIUM | — | 1 | 4.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL179455 | — | IC50 | = | 1.55 | nM | 8.81 |
| CHEMBL11805 | CAPROCTAMINE | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL95 | TACRINE | IC50 | = | 424.0 | nM | 6.37 |
| CHEMBL361165 | — | IC50 | = | 952.0 | nM | 6.02 |
| CHEMBL345124 | PROPIDIUM | IC50 | = | 32300.0 | nM | 4.49 |