Assay Detail
Binding
CHEMBL832902
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against 3-hydroxy-3-methylglutaryl-CoA reductase
35
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL402) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Three-dimensional quantitative structure (3-D QSAR) activity relationship studies on imidazolyl and N-pyrrolyl heptenoates as 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) inhibitors by comparative molecular similarity indices analysis (CoMSIA).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 8.07 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1496 | ROSUVASTATIN | 4.0 | 1 | 8.30 |
| CHEMBL1161663 | — | — | 1 | 8.24 |
| CHEMBL1487 | ATORVASTATIN | 4.0 | 1 | 8.22 |
| CHEMBL1161659 | — | — | 1 | 8.21 |
| CHEMBL1161644 | — | — | 2 | 8.16 |
| CHEMBL1161653 | — | — | 1 | 8.15 |
| CHEMBL1161651 | — | — | 1 | 8.15 |
| CHEMBL1161640 | — | — | 1 | 8.14 |
| CHEMBL1161655 | — | — | 1 | 8.14 |
| CHEMBL1161646 | — | — | 1 | 8.12 |
| CHEMBL1161664 | — | — | 1 | 8.12 |
| CHEMBL1161650 | — | — | 1 | 8.12 |
| CHEMBL1161652 | — | — | 1 | 8.10 |
| CHEMBL1161639 | — | — | 1 | 8.10 |
| CHEMBL1161648 | — | — | 1 | 8.09 |
| CHEMBL1161660 | — | — | 1 | 8.09 |
| CHEMBL1161661 | — | — | 1 | 8.08 |
| CHEMBL1161645 | — | — | 1 | 8.08 |
| CHEMBL1161647 | — | — | 1 | 8.07 |
| CHEMBL1161654 | — | — | 1 | 8.06 |
| CHEMBL1161657 | — | — | 1 | 8.06 |
| CHEMBL1161641 | — | — | 1 | 8.06 |
| CHEMBL1161665 | — | — | 1 | 8.06 |
| CHEMBL1161649 | — | — | 1 | 8.06 |
| CHEMBL1161662 | — | — | 1 | 8.05 |
| CHEMBL333760 | — | — | 1 | 8.05 |
| CHEMBL1161656 | — | — | 1 | 8.05 |
| CHEMBL1161658 | — | — | 1 | 8.03 |
| CHEMBL1161642 | — | — | 1 | 8.02 |
| CHEMBL1477 | CERIVASTATIN | 4.0 | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1496 | ROSUVASTATIN | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1161663 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL1487 | ATORVASTATIN | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1161659 | — | IC50 | = | 6.15 | nM | 8.21 |
| CHEMBL1161644 | — | IC50 | = | 6.98 | nM | 8.16 |
| CHEMBL1161653 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1161651 | — | IC50 | = | 7.15 | nM | 8.15 |
| CHEMBL1161640 | — | IC50 | = | 7.25 | nM | 8.14 |
| CHEMBL1161655 | — | IC50 | = | 7.16 | nM | 8.14 |
| CHEMBL1161646 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL1161664 | — | IC50 | = | 7.66 | nM | 8.12 |
| CHEMBL1161650 | — | IC50 | = | 7.52 | nM | 8.12 |
| CHEMBL1161652 | — | IC50 | = | 8.04 | nM | 8.10 |
| CHEMBL1161639 | — | IC50 | = | 7.89 | nM | 8.10 |
| CHEMBL1161660 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL1161648 | — | IC50 | = | 8.15 | nM | 8.09 |
| CHEMBL1161645 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL1161661 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL1161647 | — | IC50 | = | 8.52 | nM | 8.07 |
| CHEMBL1161654 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL1161657 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL1161641 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL1161644 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL1161665 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL1161649 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL333760 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1161656 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1161662 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1161658 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL1161642 | — | IC50 | = | 9.52 | nM | 8.02 |
| CHEMBL1477 | CERIVASTATIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1064 | SIMVASTATIN | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL54440 | MEVASTATIN | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2220442 | FLUVASTATIN | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1161643 | — | IC50 | < | 7.0 | nM | - |