Compound Detail
CHEMBL1161640
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Cc1cc(C)cc(-c2c(-c3ccc(F)cc3)nc(C(C)C)n2/C=C/[C@@H](O)C[C@@H](O)CC(=O)O)c1
Basic Information
| ChEMBL ID | CHEMBL1161640 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LYUVRKOESGKHFS-GZURJRJYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
466.6
MW (Da)
5.15
ALogP
5
HBA
3
HBD
95.6
PSA (Ų)
0.41
QED
1
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.14
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase CHEMBL402 | IC50 | 8.14 | 8.14 | 7.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | IC50 | = | 7.25 | nM | 8.14 | Inhibitory concentration against 3-hydroxy-3-methylglutaryl-CoA reductase | 15686906 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15686906 | 10.1016/j.bmcl.2004.12.042 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1 |
Data from ChEMBL 36 via Core Engine