Assay Detail
Binding
CHEMBL832911
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Inhibition of rat intestinal isomaltase using disaccharide
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Alpha-1-C-alkyl-1-deoxynojirimycin derivatives as potent and selective inhibitors of intestinal isomaltase: remarkable effect of the alkyl chain length on glycosidase inhibitory profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.61 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184028 | — | — | 1 | 8.46 |
| CHEMBL186291 | — | — | 1 | 7.05 |
| CHEMBL3351101 | — | — | 1 | 6.82 |
| CHEMBL187158 | — | — | 1 | 6.64 |
| CHEMBL186068 | — | — | 1 | 6.55 |
| CHEMBL364554 | — | — | 1 | 6.51 |
| CHEMBL186150 | — | — | 1 | 6.35 |
| CHEMBL187208 | — | — | 1 | 6.28 |
| CHEMBL362754 | — | — | 1 | 5.85 |
| CHEMBL1029 | MIGLUSTAT | 4.0 | 1 | 5.57 |
| CHEMBL3349976 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184028 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL186291 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3351101 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL187158 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL186068 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL364554 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL186150 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL187208 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL362754 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1029 | MIGLUSTAT | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3349976 | — | IC50 | = | 115000.0 | nM | - |