Assay Detail
Binding
CHEMBL832972
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Inhibitory concentration against Acetylcholinesterase from bovine erythrocytes after 45 min incubation
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 9.19 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2113368 | — | — | 1 | 9.59 |
| CHEMBL555666 | — | — | 1 | 9.57 |
| CHEMBL557155 | — | — | 1 | 9.44 |
| CHEMBL2113367 | — | — | 1 | 9.36 |
| CHEMBL534932 | — | — | 1 | 9.19 |
| CHEMBL555214 | — | — | 1 | 9.10 |
| CHEMBL539599 | — | — | 1 | 8.88 |
| CHEMBL538573 | — | — | 1 | 8.80 |
| CHEMBL535812 | — | — | 1 | 8.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2113368 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL555666 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL557155 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL2113367 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL534932 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL555214 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL539599 | — | IC50 | = | 1.31 | nM | 8.88 |
| CHEMBL538573 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL535812 | — | IC50 | = | 1.67 | nM | 8.78 |