Assay Detail
Binding
CHEMBL833011
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Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 3 expressed on CHO cell membranes
22
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.62 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184879 | — | — | 2 | 8.57 |
| CHEMBL118860 | — | — | 1 | 8.51 |
| CHEMBL334213 | — | — | 1 | 8.44 |
| CHEMBL181597 | — | — | 1 | 8.33 |
| CHEMBL187588 | — | — | 1 | 8.28 |
| CHEMBL1161691 | — | — | 1 | 8.20 |
| CHEMBL187692 | — | — | 2 | 8.15 |
| CHEMBL185100 | — | — | 1 | 8.01 |
| CHEMBL363008 | — | — | 1 | 7.77 |
| CHEMBL184349 | — | — | 1 | 7.75 |
| CHEMBL184237 | — | — | 1 | 7.72 |
| CHEMBL186921 | — | — | 2 | 7.57 |
| CHEMBL187645 | — | — | 1 | 7.29 |
| CHEMBL185447 | — | — | 1 | 6.72 |
| CHEMBL359762 | — | — | 1 | 6.66 |
| CHEMBL183688 | — | — | 1 | 6.66 |
| CHEMBL184591 | — | — | 1 | 6.43 |
| CHEMBL187061 | — | — | 1 | 6.39 |
| CHEMBL185066 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184879 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL184879 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL118860 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL334213 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL181597 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL187588 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL1161691 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL187692 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL187692 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL185100 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL363008 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL184349 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL184237 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL186921 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL186921 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL187645 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL185447 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL359762 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL183688 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL184591 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL187061 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL185066 | — | IC50 | = | 1200.0 | nM | 5.92 |