Assay Detail
Binding
CHEMBL833012
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Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
21
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.72 | 8.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184879 | — | — | 2 | 8.08 |
| CHEMBL1161691 | — | — | 1 | 7.82 |
| CHEMBL181597 | — | — | 1 | 7.50 |
| CHEMBL184349 | — | — | 1 | 7.07 |
| CHEMBL187588 | — | — | 1 | 6.92 |
| CHEMBL334213 | — | — | 1 | 6.85 |
| CHEMBL363008 | — | — | 1 | 6.82 |
| CHEMBL187692 | — | — | 2 | 6.75 |
| CHEMBL118860 | — | — | 1 | 6.58 |
| CHEMBL186921 | — | — | 2 | 6.12 |
| CHEMBL185447 | — | — | 1 | 6.06 |
| CHEMBL184237 | — | — | 1 | 6.04 |
| CHEMBL184591 | — | — | 1 | 5.20 |
| CHEMBL359762 | — | — | 1 | - |
| CHEMBL183688 | — | — | 1 | - |
| CHEMBL187645 | — | — | 1 | - |
| CHEMBL185066 | — | — | 1 | - |
| CHEMBL187061 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184879 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL1161691 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL184879 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL181597 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL184349 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL187588 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL334213 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL363008 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL187692 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL118860 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL187692 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL186921 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL185447 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL184237 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL186921 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL184591 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL183688 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL359762 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL187645 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL185066 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL187061 | — | IC50 | > | 10000.0 | nM | - |