Assay Detail
Binding
CHEMBL833013
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Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 5 expressed on CHO cell membranes
22
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.67 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184879 | — | — | 2 | 9.24 |
| CHEMBL1161691 | — | — | 1 | 9.11 |
| CHEMBL181597 | — | — | 1 | 8.92 |
| CHEMBL184349 | — | — | 1 | 8.66 |
| CHEMBL118860 | — | — | 1 | 8.09 |
| CHEMBL334213 | — | — | 1 | 7.89 |
| CHEMBL187692 | — | — | 2 | 7.82 |
| CHEMBL187588 | — | — | 1 | 7.77 |
| CHEMBL185100 | — | — | 1 | 7.62 |
| CHEMBL184237 | — | — | 1 | 7.47 |
| CHEMBL363008 | — | — | 1 | 7.40 |
| CHEMBL186921 | — | — | 2 | 6.96 |
| CHEMBL187061 | — | — | 1 | 6.64 |
| CHEMBL187645 | — | — | 1 | 6.57 |
| CHEMBL185447 | — | — | 1 | 6.18 |
| CHEMBL185066 | — | — | 1 | 6.17 |
| CHEMBL183688 | — | — | 1 | - |
| CHEMBL184591 | — | — | 1 | - |
| CHEMBL359762 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184879 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL184879 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL1161691 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL181597 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL184349 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL118860 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL334213 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL187692 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL187588 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL185100 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL184237 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL363008 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL187692 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL186921 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL186921 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL187061 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL187645 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL185447 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL185066 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL183688 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL184591 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL359762 | — | IC50 | > | 1000.0 | nM | - |