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Assay Detail

CHEMBL833015

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Functional
Agonist activity at human Melanocortin-3 receptor as peptide required for 50% maximal cAMP release
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Melanocortin receptor 3 (CHEMBL4644)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of a beta-MSH-derived MC-4R selective agonist.
Mayer JP, Hsiung HM, Flora DB, Edwards P, Smith DP, Zhang XY, Gadski RA, Heiman ML, Hertel JL, Emmerson PJ, Husain S, O'brien TP, Kahl SD, Smiley DL, Zhang L, Dimarchi RD, Yan LZ.
J Med Chem (2005) 48 : 3095 -3098
PubMed 15857110 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 9.17 9.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL408257 1 9.17

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL408257 EC50 = 0.68 nM 9.17