Assay Detail
Functional
CHEMBL833076
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against HIV-1 mutant strain 103N
58
Total Activities
58
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
4-benzyl- and 4-benzoyl-3-dimethylaminopyridin-2(1H)-ones, a new family of potent anti-HIV agents: optimization and in vitro evaluation against clinically important HIV mutant strains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 58 | 6.84 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190941 | — | — | 1 | 8.70 |
| CHEMBL185715 | — | — | 1 | 8.70 |
| CHEMBL182921 | — | — | 1 | 8.52 |
| CHEMBL363952 | — | — | 1 | 8.52 |
| CHEMBL188580 | — | — | 1 | 8.22 |
| CHEMBL434518 | — | — | 1 | 8.22 |
| CHEMBL182580 | — | — | 1 | 8.10 |
| CHEMBL366692 | — | — | 1 | 8.00 |
| CHEMBL188547 | — | — | 1 | 8.00 |
| CHEMBL188941 | — | — | 1 | 8.00 |
| CHEMBL183249 | — | — | 1 | 8.00 |
| CHEMBL361069 | — | — | 1 | 7.70 |
| CHEMBL189760 | — | — | 1 | 7.70 |
| CHEMBL188489 | — | — | 1 | 7.70 |
| CHEMBL187786 | — | — | 1 | 7.70 |
| CHEMBL188223 | — | — | 1 | 7.70 |
| CHEMBL184294 | — | — | 1 | 7.70 |
| CHEMBL338047 | — | — | 1 | 7.52 |
| CHEMBL182846 | — | — | 1 | 7.52 |
| CHEMBL188877 | — | — | 1 | 7.52 |
| CHEMBL187305 | — | — | 1 | 7.40 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.40 |
| CHEMBL185487 | — | — | 1 | 7.40 |
| CHEMBL186390 | — | — | 1 | 7.30 |
| CHEMBL189458 | — | — | 1 | 7.30 |
| CHEMBL361250 | — | — | 1 | 7.30 |
| CHEMBL361479 | — | — | 1 | 7.22 |
| CHEMBL182299 | — | — | 1 | 7.00 |
| CHEMBL188878 | — | — | 1 | 7.00 |
| CHEMBL185865 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190941 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL185715 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL363952 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL182921 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL188580 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL434518 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL182580 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL366692 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL188547 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL188941 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL183249 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL187786 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL189760 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL361069 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL188489 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL188223 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL184294 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL338047 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL182846 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL188877 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL187305 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL185487 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL361250 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL186390 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL189458 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL361479 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL182299 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL188878 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL185865 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL359749 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL362435 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL182725 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL366120 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL181683 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL189030 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL184934 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL181497 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL188995 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL364403 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL181747 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL185622 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL426242 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL35033 | EMIVIRINE | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL363066 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL188745 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL186129 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL187515 | — | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL361839 | — | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL188595 | — | IC50 | = | 2510.0 | nM | 5.60 |