Assay Detail
Functional
CHEMBL833120
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to reduce HIV-1-induced cytopathic effect in MT-4 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.60 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL393003 | — | — | 1 | 6.62 |
| CHEMBL362924 | — | — | 1 | 6.06 |
| CHEMBL53554 | THIAZOLOBENZIMIDAZOLE | — | 1 | 5.96 |
| CHEMBL192499 | — | — | 1 | 5.55 |
| CHEMBL192310 | — | — | 1 | 5.43 |
| CHEMBL192976 | — | — | 1 | 5.42 |
| CHEMBL370921 | — | — | 1 | 5.20 |
| CHEMBL191692 | — | — | 1 | 4.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL393003 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL362924 | — | EC50 | = | 870.0 | nM | 6.06 |
| CHEMBL53554 | THIAZOLOBENZIMIDAZOLE | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL192499 | — | EC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL192310 | — | EC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL192976 | — | EC50 | = | 3790.0 | nM | 5.42 |
| CHEMBL370921 | — | EC50 | = | 6350.0 | nM | 5.20 |
| CHEMBL191692 | — | EC50 | = | 29600.0 | nM | 4.53 |