Assay Detail
Functional
CHEMBL833121
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration against whole-cell patch clamp from mouse HEK293 cells
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and KCNQ2 opener activity of N-(1-benzo[1,3]dioxol-5-yl-ethyl, N-[1-(2,3-dihydro-benzofuran-5-yl)-ethyl, and N-[1-(2,3-dihydro-1H-indol-5-yl)-ethyl acrylamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.62 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL180886 | — | — | 2 | 7.70 |
| CHEMBL176931 | — | — | 1 | 7.22 |
| CHEMBL183979 | — | — | 1 | 6.48 |
| CHEMBL363544 | — | — | 1 | 6.37 |
| CHEMBL41355 | EZOGABINE | 4.0 | 1 | 5.89 |
| CHEMBL317935 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL180886 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL176931 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL180886 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL183979 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL363544 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL41355 | EZOGABINE | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL317935 | — | EC50 | = | 3200.0 | nM | 5.50 |